Novel Strategies in the Early Detection and Treatment of Endothelial Cell-Specific Mitochondrial Dysfunction in Coronary Artery Disease

Although elevated cholesterol and other recognised cardiovascular risk factors are important in the development of coronary artery disease (CAD) heart attack, susceptibility humans to this fatal process is distinct from animals. Mitochondrial dysfunction cells arterial wall, particularly endothelium, has been strongly implicated pathogenesis CAD. In manuscript, we review established evidence mechanisms detail explore potential opportunities arising analysing mitochondrial function patient-derived such as endothelial colony-forming easily cultured venous blood. We discuss how emerging technology knowledge may allow us measure a biomarker for diagnosis management. also “pros cons” animal models atherosclerosis, cell provide develop novel therapies relevant humans. Finally, several targets that potentially alleviate working both via direct indirect evaluate effect classes compounds context.